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Médico responsável por ensaios de droga preventiva contra HIV emocionada com resultados

A prof Linda-Gail Bekker, médica responsável pelos ensaios de 💻 uma nova droga preventiva contra o HIV, não conteve as emoções ao ouvir os resultados do estudo. "Eu literalmente chorei," 💻 disse a prof Bekker.

"Tenho 62 anos, vivi através dessa epidemia... Eu tive familiares que morreram de HIV, assim como muitos, 💻 muitos africanos – muitas pessoas bet online todo o mundo," ela disse.

O problema de como prevenir a infecção pelo HIV, especialmente 💻 bet online meninas adolescentes e jovens mulheres, parecia "intratável", disse a prof Bekker. No entanto, o lenacapavir ofereceu proteção total a 💻 milhares de mulheres entre 16 e 25 anos na África do Sul e Uganda.

A droga pode dar a jovens mulheres 💻 maior agência sobre suas vidas e sexualidade, espera ela, e potencialmente eliminar a transmissão materno-infantil do vírus.

Os resultados do ensaio 💻 Purpose 1 levaram a um aplauso de pé para a prof Bekker, diretora executiva da Desmond Tutu Health Foundation, quando 💻 apresentou-os na conferência Aids 2024 bet online Munique esta semana.

"Ainda agora, quando olho para essa [gráfico de resultados], tenho arrepios," disse 💻 a prof Bekker.

O HIV surgiu bet online 1981 como uma doença misteriosa e aterrorizante que, na época, era uma sentença de 💻 morte. Demorou até 1983 para que os cientistas identificassem que o vírus HIV estava por trás dele, e outros dois 💻 anos para o primeiro teste ser desenvolvido para detectar o vírus.

Houve grandes progressos científicos nos últimos anos, e as drogas 💻 antirretrovirais permitem que as pessoas vivam com HIV tenham vidas saudáveis. As drogas de profilaxia pré-exposição (PrEP) podem proteger contra 💻 a infecção.

Mas elas não estão alcançando todas as pessoas que precisam delas e, enquanto a maioria das novas infecções agora 💻 ocorre fora da África subsarariana, a ONU diz que a incidência de HIV entre adolescentes e jovens mulheres ainda é 💻 "extraordinariamente alta" bet online partes da região, com mais de 150.000 infectadas lá no ano passado.

Em uma parte comparativa do ensaio 💻 da prof Bekker, as mulheres foram solicitadas a tomar comprimidos diariamente como PrEP contra o HIV. Elas continuaram a se 💻 infectar – porque, explica a prof Bekker, muitas delas de fato não tomavam as pílulas diariamente.

Isto ilustra por que os 💻 resultados para uma droga que só precisa ser injetada duas vezes por ano têm gerado tanta emoção. Líderes no campo 💻 da prevenção do HIV descrevem a droga como um "milagre" com o potencial de ser um "cambiante de jogo".

"Sabemos que 💻 a adesão a qualquer coisa é mais desafiadora para jovens pessoas – e isso porque eles estão ocupados, suas vidas 💻 estão cheias, eles têm coisas a fazer, lugares para estar," disse a prof Bekker.

A prof Bekker espera que o lenacapavir 💻 dê a meninas e jovens mulheres que correm risco de infecção pelo HIV maior controle sobre suas próprias vidas.

"Você poderia 💻 imaginar que você poderia entrar silenciosamente," ela disse, "sob a aparência de obter seu contraceptivo; ninguém sequer precisa saber."

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    Previous chapters:

    The roulette bias winning method of García Pelayo

    Betting system for

    biased wheels

    As we can observe, if we have a 👌 thousand spins taken from a truly random

    table, without bias, we would hardly find the most spun number having something 👌 beyond

    15 positives. Likewise, we have a soft limit for the best two numbers, the two which

    have been spun 👌 the most, of +26. If we continue searching for different groups of best

    numbers, we can center in the sum 👌 of the best nine, which have a soft limit of +67. Why

    the soft limit only? Because the hard limit 👌 is too erratic and luck might make a number

    to fire-up without actually having any bias. It is more trustworthy 👌 to work with the

    soft limit, which occurs 95% of the time, making decisions based on it. These tables

    are 👌 more reliable the larger the numerical group is. Application to a single number

    being more doubtful than the sum of 👌 the best six, where it is harder for luck to

    interfere in a decisive manner. I make the study only 👌 up to the best nine, because if

    there are ten or more best numbers outside the limit, it tells the 👌 table is entirely

    good, and this is already studied on the first part.

    How do these tables complement the

    previous analysis? 👌 It might be the case that a roulette as a whole doesn’t goes beyond

    the soft limit, as we studied 👌 at the beginning, but the best four numbers do go beyond.

    They can be bet without much risk, awaiting to 👌 collect more data which defines with a

    higher accuracy the quality of the current roulette table. When a roulette is 👌 truly

    good, we will likewise reinforce on its quality by proving it does go outside of the

    limits set on 👌 these tables.

    Always using simulation tests on the computer, this is, in

    a experimental non-theoretical way, I studied other secondary limits 👌 which assist to

    complete the analysis of any statistics taken from a roulette. For instance, “how many

    consecutive numbers, as 👌 they are ordered on the wheel, can be throwing positives?”, or

    “How many positives can two consecutive numbers have as 👌 a maximum?”. I do not show

    these tables because they are not essential and only confirm BIAS which should have

    👌 been detected by the tables previously shown. Any way, we will see some practical

    examples below.

    So far the system was 👌 based on evidence that -although simulated- was

    being empirical; these were made with the help of the computer in order 👌 to verify the

    behavior of a random roulette.

    I found the limits up to where luck alone could take it,

    then 👌 I was able to effectuate a comparison with real-life statistics from machines

    which were clearly showing result outside the limits 👌 of pure chance, this is, they

    pointed to trends that would remain throughout its life if their materials would not

    👌 suffer alterations. These physical abnormalities could be due to pockets of unequal

    size, however small this inequality, lateral curvatures leaving 👌 sunken areas with the

    counterweight of other raised areas. Or even a different screwing of the walls from the

    pockets 👌 collecting the ball so that a harder wall means more bounce. With the

    consequent loss of results that are increased 👌 in the neighboring pockets which collect

    these bounced balls with a higher frequency than normal.

    On theoretical grounds I

    studied areas 👌 of mathematics unknown to me, in the probability branch, and worked a lot

    with the concept of variance and standard 👌 deviations. They helped me, but I could not

    apply them correctly given the complexity of roulette, that is more like 👌 a coin with 18

    sides and 19 crosses bearing different combinatorial situations, which invalidate the

    study with binomials and similar.

    The 👌 major theoretical discovery was forwarded to me

    by a nephew, who was finishing his career in physics. He referred me 👌 some problems on

    the randomness of a six-sided die. To do this they were using a tool called the « 👌 chi

    square », whose formula unraveled -with varying degrees of accuracy- the perfection or

    defects from each drawn series. How 👌 come nobody had applied that to roulette?

    I handled

    myself with absolute certainty in the study of the machines, to which 👌 the fleet had

    already pulled out great performance up to that date, thanks to our experimental

    analysis, but theoretical confirmation 👌 of these analyzes would give me a comforting

    sense of harmony (In such situations I’m always humming «I giorni

    dell’arcoballeno»*.

    We 👌 carefully adapt this formula to this 37-face die and it goes as

    follows:

    The chi square of a random roulette should 👌 shed a number close to 35.33. Only

    5% of the time (soft limit) a number of 50.96 can be reached 👌 -by pure luck- and only

    0.01% of the time it will be able to slightly exceed the hard limit of 👌 67.91.

    We had to

    compare these numbers with those from the long calculations to be made on the

    statistics from the 👌 real wheel we were studying. How are these calculations made?

    The

    times the first number has showed minus all tested spins 👌 divided by 37, all squared,

    and divided by the total of analyzed spins divided by 37.

    Do not panic. Let’s suppose

    👌 the first number we analyze is the 0, to follow in a clockwise direction with all other

    roulette numbers. Let’s 👌 suppose on a thousand spins sample number 0 has come out 30

    times:

    (30-1000/37) squared and the result divided by (1000/37) 👌 = 0.327

    The same should

    be done with the following number, in this case in wheel order, proceeding with 32 and

    👌 following with all roulette numbers. The total sum of results is the chi square of the

    table. When compared with 👌 the three figures as set out above we will find if this

    machine has a tendency, more or less marked, 👌 or it is a random table instead.

    The

    calculation, done by hand, frightens by its length but using a computer it 👌 takes less

    than a flash.

    Statistical analysis of numbers and wheel bias identification

    strategy

    While in my experimental tests I only watched 👌 leader numbers , this chi-square

    test also has in mind those numbers that come out very little and also unbalance 👌 the

    expected result.

    There was a moment of magic when I found that the results of the

    previous tables were perfectly 👌 in accordance with the results that the chi-square test

    threw.

    With all these weapons for proper analysis I did a program 👌 from which, finally,

    we’ll see some illustrations:

    TOTAL POSITIVE + 127 HIGHER + 24 L1 + 41 L2 + 70 L3 👌 + 94

    L4 + 113

    LB + 174 A + 353 B + 243 C + 195 NA 4 AG 60 👌 AD 46 N.° P 12 SPINS 10.000

    CHI

    37,18 50,96 67,91 35,33 DV-7,51 ROULETTE/DAY: RANDOM

    *LB = Límite blando = Soft

    limit.

    In 👌 this chart I created throwing 10,000 spins to simulate a random table, we can

    find all patterns of randomness; this 👌 will serve to compare with other real tables

    we’ll see later.

    In the bottom of the table, to the left at 👌 two columns, there are all

    European roulette numbers placed on its actual disposition starting at 0 and continuing

    in clockwise 👌 direction (0, 32 15, 19, 4, 21, 2, 25, etc.). We highlighted those which

    have appeared more, not only based 👌 on their probability, which is one time out of 37,

    but also based on the need to profit, i.e. more 👌 than once every 36.

    If the average to

    not lose with any number would be 1.000/36 = 27.77, our 0 has 👌 come out forty times;

    therefore it is on 40, to which we subtract 27.77 = 12.22. Which are its positives, 👌 or

    extra shows; therefore we would have gain. When 20 is – 4 4, 7 8 it is the number 👌 of

    chips lost on the 10,000 spins thrown.

    In the first row we find the total positive sum

    of all the 👌 lucky numbers is +127 (the mean of a random table in our first table is

    +126), away from the soft 👌 limit* (*Soft limit = Límite blando = LB), which is at the

    beginning of the second row, and which for 👌 that amount of spins is +174. Next to it is

    the reference of known biased tables, (All taken from the 👌 first table) which shows that

    even the weakest (table C) with +195 is far from the poor performance which begins 👌 to

    demonstrate that we are in front of a random table where drawn numbers have come out by

    accident, so 👌 it will possibly be others tomorrow.

    Returning to the first row we see

    that our best number has +24 (it is 👌 2) but that the limit for a single number ( L l )

    is +41, so it is quite normal 👌 that 2 has obtained that amount, which is not

    significant. If we want to take more into account we are 👌 indicated with L2, L3 and L4

    the limits of the two, three and four best numbers, as we saw in 👌 the second tables (our

    two best would be 2 and 4 for a total of +42 when their limit should 👌 be +70). Nothing

    at all for this part.

    In the middle of the second row NA 4 it means that it 👌 is

    difficult to have over four continuous single numbers bearing positives (we only have

    two). AG 60 tells us that 👌 the sum of positives from continuous numbers is not likely to

    pass sixty (in our case 0 and 32 make 👌 up only +21). AD 46 is a particular case of the

    sum of the top two adjacent numbers (likewise 0 👌 and 32 do not reach half that limit).

    After pointing out the amount of numbers with positives (there are 12) 👌 and the 10,000

    spins studied we move to the next row which opens with the chi square of the table.

    In

    👌 this case 37,18 serves for comparison with the three fixed figures as follow: 50.96

    (soft limit of chi), 67.91 (hard 👌 limit) and 35.33 which is a normal random table. It is

    clear again that’s what we have.

    Follows DV-751 which is 👌 the usual disadvantage with

    these spins each number must accumulate (what the casino wins). Those circa this amount

    (the case 👌 of 3) have come out as the probability of one in 37 dictates, but not the one

    in 36 required 👌 to break even. We conclude with the name given to the table.

    From this

    roulette’s expected mediocrity now we move to 👌 analyze the best table that we will see

    in these examples. As all of the following are real tables we 👌 played (in this case our

    friends “the submarines” *) in the same casino and on the same dates. The best, 👌 table

    Four:

    (* Note: “Submarines” is the euphemism used by Pelayo to name the hidden players

    from his team).

    TOTAL POSITIVES + 👌 363 HIGHER + 73 L1 + 46 L2 + 78 L3 + 105 L4 + 126

    LB

    + 185 A + 👌 447 B + 299 C + 231 NA 4 AG 66 AD 52 N.° P 13 SPINS 13.093

    CHI 129,46 50,96

    👌 67,91 35,33 DV-9,83 ROULETTE/DAY: 4-11-7

    What a difference! Here almost everything is

    out of the limits: the positive (+363) away from 👌 the soft limit of 185. The table does

    not reach A but goes well beyond the category of B. The 👌 formidable 129.46 chi, very far

    from the fixed hard limit of 67.91 gives us absolute mathematical certainty of the very

    👌 strong trends this machine experience. The magnificent 11 with +73 reaches a much

    higher limit of a number (L1 46), 👌 11 and 17 break the L2, if we add 3 they break the

    L3, along with 35 they break the 👌 L4 with a whopping +221 to fulminate the L4 (126). It

    doesn’t beat the mark for contiguous numbers with positives 👌 (NA 4), because we only

    have two, but AG 66 is pulverized by the best group: 35 and 3,along with 👌 that formed by

    17 and 37, as well as the one by 36 and 11. The contiguous numbers that are 👌 marked as

    AD 52 are again beaten by no less than the exact three same groups, showing themselves

    as very 👌 safe. Finally it must be noted that the large negative groups ranging from 30

    to 16 and 31 to 7 👌 appear to be the mounds that reject the ball, especially after seeing

    them in the graph on the same arrangement 👌 as found in the wheel.

    Playing all positive

    numbers (perhaps without the 27) we get about 25 positive gain in one 👌 thousand played

    spin (the table is between B and A, with 20 and 30 positives of expectation in each

    case). 👌 It is practically impossible not winning playing these for a thousand spins,

    which would take a week.

    Another question is chip 👌 value, depending on the bank we have.

    My advice: value each chip to a thousandth of the bank. If you 👌 have 30,000 euros, 30

    euros for each unit. These based on the famous calculations of “Ruin theory” precisely

    to avoid 👌 ruining during a rough patch.

    Another interesting table for us, the

    Seven:

    TOTAL POSITIVES + 294 HIGHER + 83 L1 + 56 👌 L2 + 94 L3 + 126 L4 + 151

    LB + 198 A +

    713 B + 452 C + 325 👌 NA 4 AG 77 AD 62 N.° P 13 SPINS 21.602

    CHI 77,48 50,96 67,91 35,33

    DV-16,22 ROUILETTE/DAY: 7-9-3

    This table seven, 👌 with many spins, is out of bounds in

    positives and chi, but the quality is less than C. It has, 👌 however, a large area

    ranging from 20 to 18 having almost +200 by itself, that breaks all NA, AG and 👌 AD,

    which while being secondary measures have value here. No doubt there’s something,

    especially when compared with the lousy zone 👌 it is faced with from 4 to 34 (I wouldn’t

    save the 21). Here should be a “downhill area” which 👌 is detected in this almost

    radiography. The slope seems to end at the magnificent 31. Also add the 26. Finally, 👌 a

    typical roulette worth less than average but more than B and C which is out of bounds

    with three 👌 well defined areas that give a great tranquility since even as it doesn’t

    has excessive quality, with many balls it 👌 becomes very safe.

    Table Eight:

    TOTAL

    POSITIVES + 466 HIGHER + 107 L1 + 59 L2 + 99 L3 + 134 L4 👌 + 161

    LB + 200 A + 839 B + 526

    C + 372 NA 4 AG 83 AD 73 N.° 👌 P 14 SPINS 25.645

    CHI 155,71 50,96 67,91 35,33 DV-19,26

    ROULETTE/DAY: 8-12-7

    It is the first time that we publish these authentic 👌 soul

    radiographies of roulette. My furthest desire is not to encourage anyone who,

    misunderstanding this annex, plays happily the hot 👌 numbers on a roulette as seen out

    while dining. That’s not significant and I certainly do not look forward to 👌 increase

    the profits of the casinos with players who believe they are practicing a foolproof

    system. It takes many spins 👌 to be sure of the advantage of some numbers. Do no play

    before.

    Be vigilant when you find a gem to 👌 detect they do not touch or modify it in

    part or its entirety. If this happens (which is illegal but 👌 no one prevents it), your

    have to re-study it as if it were a new one.

    Regardless of how much advantage 👌 you have

    (and these roulette tables are around 6% advantage, ie, more than double the 2.7%

    theoretical advantage of the 👌 casino) it does not hurt that luck helps. I wish so to

    you.

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